Desktop shortcut for snapshot  

Prusa slicer does not have any concept of ‘snapshots’. When you start it, it starts with the last used selected profiles, so print, filament and printer. 
However when you save a project (file>save project as) it creates a .3mf file, that project stores the profiles you have selected.  This means that you can use saved projects to in effect load a predetermined selection. As you can assign PS as the default program for a .3mf file you can then start PS which will open the 3mf you double click on and then load in the profiles. 

Can be done with a script or batch file, yes

Posted by: @donob

[...] Is there any way to start a snapshot directly via a desktop shortcut?

It depends on what you mean by "snapshot". If you just want to start with specific settings, you can create a script/batch file to use the --load command line parameter to point to one or more .ini config files. Settings are loaded in the order the files are specified, so if there are any duplicates, the last change will remain in effect. I haven't worked with this for a while, but I believe it will still work with recent PrusaSlicer releases.

If by "snapshot" you mean a full .3MF project file complete with the part to be printed, you can specify an STL or 3MF project file as on the command line, as well as zero or more .ini configs with the load --load option.

The Slic3r (on which PrusaSlicer is based) command line options should still mostly work. PrusaSlicer has expanded the options somewhat. 

Possible conflict with both loading .ini files and specifying 3MF file on command line

Just a note that there was, at least as of 2020, a problem with specifying both .ini configs and a 3MF project file on the command line. Not sure if this has been corrected, or is simply the order of precedence. It's something that likely requires a bit of testing. In any case, you can load up a 3MF project file on startup.

Works

That works, Thanks 🙂