What should I be fixing?  

RE:

I've had issues like this over the years and the causes are numerous.

Looking at your pics I want to ask: 

1. It is possible that the glue stick was thickly clumped on the bed before you did the print? Sometimes excessive glue stick will prevent the filament from making consistent bed contact.  That's why I stopped using it. When adhesion or release agents are needed,  I use Aquanet hairspray instead. 

2. Any chance your filament may contain excessive moisture?  No I'm not channeling Diem (forum joke).  You said your using PLA, but in my experience these kinds of artifacts could definitely be caused by uneven filament expansion through the nozzle.  

3. The first layer appearance could also indicate uneven adhesion to the bed for other non-glue stick related reasons.  In any case when the first layer is not flat, the resulting displacement of the filament in the + Z direction can translate through the entire model. 

4.  In some cases over extrusion could be the culprit. 

I'm sure others will chime in, but those are the areas I would check if this were my print. 

G-code is of little use in these cases, either link to the original file or, better, perform your slice and save your project as a .3mf file

Files > Save Project as

Zip the .3mf and post it here. It will contain both your part and your settings for us to diagnose.

However:  Give your print sheet a thorough clean, DO NOT use gluestick - you don't need it with PLA and it's likely to confuse the probe due to the soft layer.

I see nothing to justify 0.1mm layers, change to a 0.2mm layer profile.

Try 3 or 4 perimeters. 

If you are using adaptive cubic try 15% - the value is the top layer support, the adaption is applied to lower layers.

Cheerio,

RE: What should I be fixing?

Hi, thanks for your replies.

1. Gluestick use: Yes, there may be clumps of glue that could produce this issue. I used glue because the previous failed print had the organic supports either getting knocked off or detached from the bed on their own. That was on the textured bed, and I was not too fond of the texture appearing on the clicker.

2. The rest of the print surface was fairly good so I see moisture as a low possibility event, and these uneven textures look patterned. Those areas seem to be where the adaptive cubic infill meets the perimeters. The filament is new from delivery, dried in a heated dryer with desiccant and the printer feeds directly from it.

3. An uneven first layer could be an issue. I regret not sticking around to observe the first layer. I'll have a look at that in the next print. Thanks.

4. Overextrusion: Possibly. I haven't checked the QR code on the Prusament spool. It's using the stock Prusament filament profile in PrusaSlicer, though.

5. I'm using 0.1mm layer height as the top of the print is a curved surface and I want the striations to be minimal. It's a gift for a friend that I'm trying to introduce to 3D printing so a nice-looking print is important.

6. I had it at 3 perimeters. I'm thinking if this, together with the infill pattern is creating the "over-extrusions" on the angled surface.

these uneven textures look patterned.

Yes, they are the opposite of a Wagner tension field causing repeated evasive patterns of compressive stress relief. 

Overextrusion:

This looks like overextrusion but instead the printer is trying to extrude the correct amount when something, probably excess glue, has already taken some of the space.

I'm using 0.1mm layer height as the top of the print is a curved surface

So use variable layer height to set close layers at the top and thick ones for the rest.

I had it at 3 perimeters.

So try 4.

Cheerio,