Large blobs being created and causing the print head to crash.
Pictures Set #1 and Set #2 first.
I don't print a ton, but recently I've been trying to get into gridfinity and got some good prints in. Took a week off and came back to a printer that... fails with layer shifting for gridfinity base plates, which I've printed before without issue. The first few failures I'm not sure why they failed, but the most recently 3 I'm 100% sure failed due to very large filament blobs ending up on the print. The print head inevitably runs into the blobs, crashes, and causes massive layer shifting. So far that I've tried, smaller prints have been fine. There is something about the larger stuff that recently has not gone well.
Being in technology for my day job, I'm not going to say "Nothing has changed" because clearly something has. But nothing that *I'm aware of* has changed. Between successful prints and failed prints I have no changed Slicer version, I've not changed firmware version and I'm using some of the same filaments as before. I asked reddit and followed every suggestion I got there as well.
Prusa Mk4 w/ 6.0 firmware. 0.6mm Prusa Nozzle. Prusament PETG & Overture PETG. PrusaSlicer 2.7.4 w/ default 0.32mm speed setting & input shaping turned on.
I've re-run the test/calibration. Checked X/Y belt tuning. Cleaned the nozzle exterior, run cleaner filament through the nozzle several times. There is no build up on the sock/nozzle. The filament has been dried (repeatedly and recently), it prints without pops or crackles. Bed adhesion is perfect and the first layer goes down perfectly.
RE:
The first thing I would try is drying your filament as it could have absorbed water in a week, particularly if not stored adequately over that week.
Pretty much every problem I have had has been wet filament.
Edit: just reread the last paragraph and see you've done that